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RISS 인기검색어
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- 저자 : 장중영 ( Jung Young Jang ) (검색결과 2 건)
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연구노트 : 3T3-L1 지방세포내 ROS 생성에 대한 천년초 열수 및 에탄올 추출물의 항산화 효과
윤보라 ( Bo Ra Yoon ),이영준 ( Young Jun Lee ),김선구 ( Sun Gu Kim ),장중영 ( Jung Young Jang ),이효구 ( Hyo Ku Lee ),이성갑 ( Seong Kap Rhee ),홍희도 ( Hee Do Hong ),최현선 ( Hyeon Son Choi ),이부용 ( Bo Yong Lee ),이옥환 ( Ok Hw 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2012 한국식품저장유통학회지 Vol.19 No.3
Recently, NADPH oxidase 4 (NOX4)-mediated generation of intracellular reactive oxygen species (ROS) was proposed to accelerate adipogenesis of 3T3-L1 cell. We have previously shown that Cheonnyuncho (Opuntia humifusa) extract significantly inhibited adipocyte differentiation via downregulation of PPARγ (peroxisome proliferator-activated receptor gamma) gene expression. In this study, we focused on the molecular mechanism(s) of NOX4, G6PDH (glucose-6-phosphate dehydrogenase) and antioxidant enzymes in anti-oxidative activities of 3T3-L1 adipocytes. Our results indicate that Cheonnyuncho extracts markedly inhibits ROS production during adipogenesis in 3T3-L1 cells. Cheonnyuncho extracts suppressed the mRNA expression of the pro-oxidant enzyme such as NOX4 and the NADPH-producing G6PDH enzyme. In addition, treatment with Cheonnyuncho extract was found to upregulate mRNA levels of antioxidant enzymes such as Mn-SOD (manganese-superoxide dismutase), Cu/Zn-SOD (copper/zinc-SOD), glutathione peroxidase (GPx), glutathion reductase (GR), and catalase, all of which are important for endogenous antioxidant responses. These data suggest that Cheonnyuncho extract may be effective in preventing the rise of oxidative stress during adipocyte differentiation through mechanism(s) that involves direct down regulation of NOX4 and G6PDH gene expression or via upregulation of endogenous antioxidant responses.
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유석영 ( Seok Yeong Yu ),이영준 ( Youg Jun Lee ),강석남 ( Suk Nam Kang ),이성갑 ( Seong Kap Lee ),장중영 ( Jung Young Jang ),이효구 ( Hyo Ku Lee ),임정호 ( Jeong Ho Lim ),이옥환 ( Ok Hwan Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.2
본 연구는 홍화씨의 식품학적 성분 및 항균활성을 분석하였다. 홍화씨의 수분함량은 5.58±0.09%, 조단백질 37.16±0.85%, 조회분 3.52±0.04%, 조지방 13.69±8.98%, 탄수화물 40.05%이었다. 홍화씨의 총 아미노산은 391.99mg%이고, 이중 필수아미노산의 함량은 122.97 mg%이었다. 홍화씨의 아미노산 중 alanine (75.43 mg%), arginine (37.97mg%) 및 aspartic acid (33.24mg%)을 많이 함유하고 있었다. 홍화씨의 주요 유리당은 fructose가 3.29%이었고, linoleicacid (C18:2)는 약 79.46%의 비율을 차지하여 홍화씨의 조지방 중 가장 많은 것으로 나타났다. 또한, Oleic acid (C18:1)도 약 40.42%를 함유하여 불포화지방산의 함유량도 매우 높게 나타났다. 홍화씨의 무기질 함량 측정 결과, K 및 Ca의 함량이 1,528 및 1,005 mg%으로 가장 많이 함유되어 있었다. 총 페놀 및 총 플라보노이드 함량은 55.52±0.99 mg GAE/g, 78.69±0.91 mg QE/g으로 나타났다. 홍화씨의 항균활성은 농도가 증가함에 따라 Staphylococeus aureus, Salmonella typhimurium, Escheria coli, Candida albicans, Bacillus cereus, Listeria monocytogenes, Vibrio parahaemolyticus 및 Clustridium perfringens 균에 대한 항균 효과가 높아지는 것으로 나타났다. This study was conducted to investigate die Physicochemical characteristic of Cart/minus tinctorius L seed and to assess its total phenol content total flavonoids content and antimicrobial activity. The moisture, crude protein, crude fat crude ash and carbohydrates of the Cars/minus tinctorius L seed were 5.58, 37.16, 13.69, 3.52. and 40.05%, respectively. Total amino acid in Carthanmus tincrorli6 L seed was 391.99 mg% The major free sugar of Cart/minus tinctorius L seed were fructose(3.29%) and sucrose( l.74%) Linoleic acid(79.46% was a major fatty acids in the crude fat of Can/minus tinctorius L seed. The K and Ca contents were the highest in Carthamus tinctorius L seed. Total phenol and total flavonoids contents of the ethanolic extract were 55.52 ± 0.99 mg GAE/g and 78.69 ± 0.91 mg QE/g, respectively. The extract from Carthamus tinctorius L seed showed growth inhibitory effect on Staphylococcus aureus, Salmonella typhimurium, Escheria coil, Candida albicans, Bacillus cereus, Listeria monocytogenes, Vibrio parahaemolyticus, and Clustridium perfringens. These results indicate that the Carthamus tinctorius L. Seed extract can inhibit food pathogen associated with total phenol and total flavonoids contents.
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