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공기중 염화비닐단량체의 포집시 공기 포집량이 파괴에 미치는 영향
윤존중,임남구,김치년,노재훈 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3
The main factors of breakthrough are known to sampling time, flow rate, concentration of the sample, temperature, humidity, and tee physical characteristics of the solid sorbent tube. However, no study has been reported the effect of temperature and sampling volume on the breakthrough of a charcoal tube during vinyl chloride monomer (VCM) sampling. The objective of this study is to suggest the optimal sampling condition during VCM sampling based on National Institute for Occupational Safety and Health(NIOSH) method. To evaluate adequate sampling volume for VCM without breakthrough, volume of 1, 2, 3, 4, and 5 L each from VCM of 1, 5, 10, 15, and 20ppm at flow rate of 0.05 L/min were sampled in 22℃ and 40℃. At 22℃, in the case of 1, 5, 10, and 15ppm, VCM was absorbed completely in first section of charcoal tube regardless of sampling volume. But in 20ppm, detection rates are 99.56℃ in first section and 0.44℃ in second section. At 40℃ of 1ppm. VCM was adsorbed completely in first section. in 10, 15, and 20ppm, detection rates of second, third, and forth sections were decreased significantly by reduction of sampling volume, In determination of breakthrough based on NIOSH method, no breakthrough was occurred in 20ppm at 22℃. At 40℃, breakthrough was occurred in 10, 15, and 20ppm when sampling volume was 5L. Although no breakthrough was occurred when sampling volume was 3L. Finally, in environment of temperature around 22℃, breakthrough may not occurred up to 20ppm during sampling for VCM. During sampling for VCM in environment of temperature around 40℃, no breakthrough occurred in 1-5ppm and 10-20ppm when sampling volume is 5L and 3L respectively. This result suggests that the sampling volume should be considered when VCM sampling under hot conditions (>22℃) by the NIOSH method No. 1007.
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대립계 포도 천창개폐형 비가림하우스의 최적 파이프 규격
염성현(Sung Hyun Yum),윤남구(Nam Gyu Yun),김경원(Gyeong Won Kim),이성현(Sung Hyoun Lee),조용호(Yong Ho Cho),박서준(Seo Jun Park),박문균(Mun Kyun Park) (사)한국생물환경조절학회 2007 생물환경조절학회지 Vol.16 No.4
본 연구는 기존 비닐하우스 아연도 강관을 사용한 하우스 폭 3.6m와 5m 천창개폐형 대립계 포도 비가림하우스에 대한 구조적 안전성을 검토하고, 인장강도 400Nㆍ㎜?²(SGH400 등) 이상의 파이프를 사용하는 조건에서 하우스 폭 5m인 천창개폐형 대립계 포도 비가림하우스에 대하여 구조적으로 안전한 최적 파이프 규격을 제시하고자 수행하였다. 주기둥 3m×서까래 60 ㎝인 천창개폐형 3.6m 비가림하우스의 경우, 적설심 35㎝에서는 구조적으로 안전한 것으로 분석되었으나 측면 및 전후면 풍속 35mㆍs?¹에서는 불안전한 것으로 나타났으며, 동일 주기둥과 서까래 간격을 갖는 천창개페형 5m 비가림하우스의 경우에는 적설심 35와 풍속 35mㆍs?¹에서 모두 불안전하여 구조보강이 필요한 것으로 분석되었다. 그리고 동일 주기둥과 서까래 간격을 가지나 인장강도 400Nㆍ㎜?² 이상을 갖는 파이프를 사용하는 조건에서 천창개폐형 5m 비가림하우스의 최적 파이프 규격은 지붕높이 1.6m(아치형)와 지붕높이 1.8(복숭아형)에 대하여 동일하게 두 경우로 규격화할 수 있었다. 즉, 안전풍속 35mㆍs?¹와 안전적 설심 40㎝에서 구조적으로 안전한 서까래 규격은 Ф31.8×1.5t@600이었으며, 안전풍속 30mㆍs?¹와 ss 안전적설심 35㎝에서는 서까래 Ф25.4×1.5t@600인 것으로 분석되었다. 덕면으로부터 곡부보까지의 높이는 안전적설심보다는 안전풍속에 직접적인 영향을 미치는 것으로 분석되었으며, 처마를 높임에 따라 측면풍속에 대해서는 방풍벽파이프(측벽서까래)를, 전후면 풍속에 대해서는 마구리기둥의 규격을 강화하여야 하는 것으로 분석되었다. This study was carried out to: (1) analyze structural stability of representative rainsheltering greenhouses for large-grain grapevine cultivation with widths of 3.6 and 5 m in case of using the existing pipe for agriculture; (2) present the optimum specification of pipes in the greenhouse with a width of 5 m under the condition of using the pipe of which ultimate strength has been above 400 Nㆍ㎜?²; (3) evaluate stability and also present the optimum specification of pipes as eaves height was augmented. The above analyses were done for greenhouses with roof vents and also with a main-column interval of 3 m and a rafter interval of 60㎝ First, the existing 3.6m greenhouse with a rafter of Ф25.4 × 1.5 t@600 was stable for a snow-depth of 35 ㎝ but unstable for a wind velocity of 35mㆍs?¹, Meanwhile the existing 5 m greenhouse with the same rafter was not stable for a wind velocity of 335 mㆍs?¹ as well as a snow-depth of 35㎝. This meant that existing greenhouses had to be reinforced to secure stability. Second, the specification of pipes, especially rafter, could be classified as two cases. One had a structural stability at a safe wind velocity of 35 mㆍs?¹ and a safe snow-depth of 40㎝ for which stability the rafter had to be Ф31.8 × 1.5 t@600, and the other had a stability at 30 mㆍs?¹-35㎝ at the specification of rafter Ф25.4 × 1.5 t@600. Finally, eaves height had a significant effect on safe wind velocity. But it had little influence on safe snow-depth. The results showed that the specification of side-wall pipes had to be reinforced for the safe side velocity according to the increment of eaves height and similarly the specification of fore?end post for the safe fore-end velocity.
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Hye-Kyung Park,윤남구,이지은,Sung Hu,윤소라,So Yeon Kim,홍준희,Dougu Nam,Young Chan Chae,박종배,Byoung Heon Kang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reasonable strategy for cancer therapy. However, since the existing pan-Hsp90 inhibitor does not accumulate in mitochondria, the potential anticancer activity of pan-Hsp90 inhibition has not yet been fully examined in vivo. Analysis of The Cancer Genome Atlas database revealed that all Hsp90 paralogs were upregulated in prostate cancer. Inactivation of all Hsp90 paralogs induced mitochondrial dysfunction, increased cytosolic calcium, and activated calcineurin. Active calcineurin blocked prosurvival heat shock responses upon Hsp90 inhibition by preventing nuclear translocation of HSF1. The purine scaffold derivative DN401 inhibited all Hsp90 paralogs simultaneously and showed stronger anticancer activity than other Hsp90 inhibitors. PanHsp90 inhibition increased cytotoxicity and suppressed mechanisms that protect cancer cells, suggesting that it is a feasible strategy for the development of potent anticancer drugs. The mitochondria-permeable drug DN401 is a newly identified in vivo pan-Hsp90 inhibitor with potent anticancer activity.
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