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합환파의 성분에 관한 연구 (Ⅱ) : Triterpenoid
강삼식(S. S. Kang),최재수(J. S. Choi),우원식(W. S. Woo) 한국생약학회 1982 생약학회지 Vol.13 No.1
In the previous report the isolation of 3`,4`,7-trihydroxyflavone and α-spinasteryl glucoside from the stem bark of A. julibrissin were presented (the 30th annual meeting of the Pharmaceutical Society of Korea, October, 1981). In the course of cotinuous work on the plant, from the hydrolysate of the strong uterotonic active saponin fraction 3β, 16β, 21β-tri-hydroxyolean 12-en-28-oic acid 28:21-lactone (acatic acid lactone), mp 250-51˚ [α]^20_D +10˚, was isolated. It is most probably assumed that the lactone is an artefact transformed during acid hydrolysis of the saponins.
우원식(W. S. Woo),이정규(C. K. Lee),신국현(K. H. Shin) 한국생약학회 1982 생약학회지 Vol.13 No.1
From the ether extract of the roots of A. koreana, in addition to the previously isolated coumarins from this plant such as isoimperatorin, mp, 108-10°, osthol, mp 83-4°, imperatorin, mp 104-5°and oxypeucedanin, 139-40°, three known furanocoumarins such as bergapten, mp 185-7°, isooxypeucedanin, mp 143-4°and oxypeucedanin methanolate, mp 124-7°, were newly isolated as minor coumarins. All the furanocoumarins inhibited drug metabolizing enzyme activity.
신국현(K. H. Shin),우원식(W. S. Woo),신양미(Y. M. Shin),한용봉(Y. B. Han),황영랑(Y. R. Hwang) 한국생약학회 1984 생약학회지 Vol.15 No.1
The effect of some spices on liver drug metabolizing activity was evaluated by measuring the duration of hexobarbital-induced hypnosis in mice. The experimental results obtained with 22 plant extracts were as follows; Oral administration of seven plant extracts such as Fennel seeds, Dill weads, Nutmeg, White pepper, Mace (aril), Sage leaves and Paprika to mice daily for 7 days caused a significant shortening effect on the duration of sleeping time. The treatment of mice with a single i.p. injection of 9 plant extracts resulted in a significant prolongation of sleeping time. These results strongly indicated that some spices might affect the activity of liver microsomal enzyme systems.
패장초의 Triterpenoid 및 Coumarin 성분
최재수(J. S. Choi),우원식(W. S. Woo) 한국생약학회 1982 생약학회지 Vol.13 No.1
From the chloroform soluble fraction of methanol extract of root rhizome of P. scabiosaefolia (Valerianaceae), oleanolic acid, hederagenin, a mixture of β-sitosterol and campesterol gluco and oleanolic acid 3-α-L-arabinoside were isolated and identif by spectra data. To our best knowledge, occurrence of the last compound, mp 256-8˚ in nature has not been reported in the literature. From the butanol soluble fraction, a known coumarin, esculetin was also isolated.
신국현(K. H. Shin),우원식(W. S. Woo),신양미(Y. M. Shin),이정규(C. K. Lee) 한국생약학회 1984 생약학회지 Vol.15 No.1
In a previous paper, it is reported that piperine showed a central nervous system depressant activity. On 7 daily oral administrations it caused a significant increase in hexobarbital hydroxylase, and aminopyrine N-demethylase as well as in cytochrome P-450 level in mouse liver. Above results inducer of drug metabolizing enzymes.