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Cisplatin 경동맥화학색전술 후 발생한 용혈성 요독 증후군 1예
석창현 ( Chang Hyeon Seock ),이단비 ( Danbi Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ) 대한간암학회 2012 대한간암학회지 Vol.12 No.2
Hemolytic uremic syndrome (HUS) is a rare condition compromising the clinical triad of acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. HUS may be associated with a variety of etiologies, and chemotherapeutic agents have also been reported to be associated with HUS, including mitomycin, cisplatin, bleomycin, and most recently gemcitabine. HUS also has been observed in association with a number of disseminated malignancies in adults, most typically adenocarcinoma of the stomach and breast. But there was no case report of HUS after cisplatin based transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We experienced a case of HUS after cisplatin based TACE and reported this case with several literature reviews.
석창현 ( Chang Hyeon Seock ),이단비 ( Dan Bi Lee ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),이한주 ( Han Chu Lee ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ) 대한간암학회 2012 대한간암학회지 Vol.12 No.1
According to AASLD practice guideline, for patients who present with advanced hepatocelluar carcinoma, new data indicates the efficacy of sorafenib in prolonging life. But there are no data comparing combination transarterial chemoemboliation with sorafenib to sorafenib treatment alone. We experienced a case that treated a patient with combination therapy including transarterial chemoembolization for intrahepatic hepatocelluarcarcinoma, radiation therapy for portal vein thrombosis and sorafenib treatment. He was in stable disease state after 6 months later. Therefore, it seems to be need to study for comparing combination therapy to sorafenib, or to transarterial chemoembolization.