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RISS 인기검색어
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- 저자 : 백경아(Kyeong-A Baek) (검색결과 2 건)
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안드로겐 결핍 쥐에서 운동 중재에 따른 시냅스 단백질의 발현 양상 규명
백경아(Kyeong-A Baek),지용석(Yong Seok Ji),정수진(Sujeen Jung),윤진환(Jin-Hwan Yoon) 한국생활환경학회 2021 한국생활환경학회지 Vol.28 No.5
The purpose of this experiment was to investigate the characterization of synaptic protein expression by exercise intervention in androgen-deficient rats. The experimental animals were divided into three groups (n=10 in each group): the normal control group (CON), orchiectomized(OCX+CON) and treadmill exercise group with orchiectomized(OCX+TE). The rats in the exercise group were forced to run on a treadmill for 30~45 min 5 times per week for 12 weeks. Compared to the CON group, the OCX+CON group showed significantly decreased serum testosterone levels and also, brain-derived neurotrophic factor (BDNF) and synapsin 1 (SYN1) mRNA expression in the hippocampus. Whereas, OCX+TE group was significantly increased testosterone and BDNF mRNA compared to the OCX+CON group. SYN1 mRNA was slightly increased than OCX+CON group, but was not significant different. These results suggest that exercise is one of the effective intervention strategies to prevent testosterone deficiency-mediated cognitive impairment the aging process of males.
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트레드밀 운동이 난소 절제 쥐의 지질대사 조절인자 및 지방조직 갈색화에 미치는 영향
백경아(Kyeong-A Baek),지용석(Yong Seok Ji),윤진환(Jin-Hwan Yoon) 한국생활환경학회 2021 한국생활환경학회지 Vol.28 No.2
The purpose of this study was to investigate the effects of aerobic exercise training on lipid metabolism regulators and browning of adipose tissue in ovariectomized rats. A total 36 of female Sprague-Dawley rats were divided into three groups: CON (normal control, n=12), OVA-CON (ovariectomized-control), OVA-TE (ovariectomized + treadmill exercise, n=12). The rats in the OVA-TE group were forced to run a treadmill for 30 min 4 times per week for 12 weeks. In the liver, the mRNA levels of peroxisome proliferator-activated receptor-gamma (PPARγ) and SPEBP-1 were significantly decreased in the OVA-TE group compared with the OVA-CON group (p<.05). In the gastrocnemius, the PGC-1α mRNA expression was significantly increased in the OVA-TE group compared to the OVACON group(p<.05). Also, the OVA-CON group showed significantly decreased UCP-1 mRNA levels compared to the CON group, while the OVA-TE group was significantly higher than the OVA-CON group(p<.05). These results indicate that regular aerobic exercise could improve the lipid metabolism-related factors and enhance the browning of adipose tissue in the ovariectomized rats.
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