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박희옥,Yu Miri,Sung Kyu Kang,양성익,김연정 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.1
Titanium dioxide (TiO₂ ) nanoparticle is an important product for nanotechnology because of its high stability, anticorrosion, and photocatalysis. It is also used in cosmetic and skin care products, particularly in sunblocks, where it helps to protect the skin from UV light, especially in the case of nanosized particles (⁄100 nm). There are extensive concerns on the potential risks of TiO₂nanoparticle to human health and environment. Some forms at least may be genotoxic, photocatalytic, and/or carcinogenic. In this study,we have characterized the physico-chemical properties of commercially available photocatalytic TiO₂nanoparticle and compared to cellular effects in HaCaT Cells with or without photoactivation. The present study has shown that TiO₂nanoparticles are cytotoxic to HaCaT cells even in the absence of photoactivation. This effect became more pronounced in the simultaneous irradiation of UVA dependent on photocatalytic potential of TiO₂nanoparticle. We also found that the cytotoxicity and oxidative stress of TiO₂nanoparticles strongly depends on physico-chemical properties including structure (anantase, rutile, or mixture) or photocatalytic potency of TiO₂nanoparticles.
박희옥 京畿專門大學 1998 京畿專門大學 論文集 Vol.- No.26
Kimchi is a low calorie food and high in minerals, vitamins and dietary fibers and has many lactic acid bacteria. Furthermore, in recent study, it has been reported kimchi has a antimutagenic and anticancer effect. Chinese cabbage has bioactive materials such as glucosinolate, flavonoid, phenol and sulfur containing compounds, and revealed drug metabolism, antimutagenecity, anticancer, stimulation of gastric juice excretion and chemoprotective activity. Capsaicin in red pepper powder stimulates the production of gastric juice and the sterilization of microorganism. Allyl sulfide in garlic reveals strong antimicrobial and anticancer functions. Ginger contains gingerol that stimulates circulation of the blood, perspiration effect and antimicrobial function. Lactic acid bacteria in kimchi have a antimutagenic and anticancer effect and the cell walls of lactic acid bacteria supress the tumor formation. Thus whether the bacteria are alive or dead, theantitumor activity was still effective. Kimchi with high level of dietary fiber might prevent colon cancer and ascorbic acid and carotenoid are well known antionidative, antimutagenic and anticancer compounds. Kimchi contains the highest level of ascorbic acid and carotenoids when it is fermented optimally. Phenolic compounds and chlorophyll in kimchi might show antioxidative and antimutagenic activities. It is reported that salt(NaCl) stimulates carcinogenesis. Kimchi with 3% NaCl did not show mutagenecity, but the kimchi with high level of NaCl showed comutagenecity. Thus, high level of NaCl used when kimchi making should be avoided. It has been suspected kimchi might be involved in high incidence of stomach cancer in Korea, because it has NO_(3), NO_(2), nitrosamines, NaCl and hot red pepper. But kimchi that has various bioactive materials, ascorbic acid, carotenoid, chlorophyll and many lactic acid bacteria might reveal antimutagenic and anticancer effects. The antimutagenic and anticancer effects are more increased in the optimally ripened kimchi.