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閔庚憲,趙漢栢,金鍾桓,金哲源,柳深根 대한한의학회 부인과학회 2001 大韓韓方婦人科學會誌 Vol.14 No.1
Osteoporosis is one of the most common metabolic bone disease. When the bone density is reduced to the level below the fracture threshold, the risk of fracture is greatly increased. The purpose of this study is to examine what are the effects of the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: 1. Body weight in control group showed significant increase in comparison with sham, but that in Chungahwangamy(CAH)-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham, but that in CAH-treated showed no change in coparison with control. 3. The level of serum alkaline phosphatase(ALP) activity in control group showed significant increase in comparison with sham, but that in CAH-treated showed no change in coparison with control. 4. The level of serum calcium in control group showed no change in comparison with sham, but that in CAH-treated was significantly decreased in comparison with control. 5. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in CAH-treated showed no change in comparison with control. 6. The level of serum T_3 in control group showed no change in comparison with sham, but that in CAH-treated was significantly decreased in comparison with control. 7. The level of serum T_4 in control group showed significant increase in comparison with sham, and that in CAH-treated showed significant decreased in comparison with control. 8. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham, but that in CAH-treated showed no change in comparison with control. According to the above these results, CAH has shown to be capable of preventing and curing osteoporosis caused by postmenopause.