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Spinocerebellar ataxia type 2, Slow saccades
남정무,김병건,구자성,박종무,이정주,권오현 대한임상신경생리학회 2007 Annals of Clinical Neurophysiology Vol.9 No.2
Department of Neurology, Eulji Hospital Eulji University College of Medicine, Seoul, Korea Spinocerebellar ataxia type 2 (SCA2) is characterized by progressive cerebellar ataxia and slow saccades. A 40-year-old woman presented with progressive gait disturbance and ataxia over 15 years. Neurologic examination revealed scanning speech, ataxia, and hyporeflexia. Brain CT showed diffuse atrophy of the cerebellum. Electronystagmography demonstrated slowed saccades with normal accuracy and delayed latency. The diagnosis of SCA2 was confirmed by the genetic test. Documentation of slow saccades may help differentiation among SCA subgroups.
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남정무,김병건,구자성,박종무,이정주,권오현,Nam, Jungmoo,Kim, Byung-Kun,Koo, Ja-Seong,Park, Jongmoo,Lee, JungJu,Kwon, Ohyun 대한임상신경생리학회 2007 Annals of Clinical Neurophysiology Vol.9 No.2
Spinocerebellar ataxia type 2 (SCA2) is characterized by progressive cerebellar ataxia and slow saccades. A 40-year-old woman presented with progressive gait disturbance and ataxia over 15 years. Neurologic examination revealed scanning speech, ataxia, and hyporeflexia. Brain CT showed diffuse atrophy of the cerebellum. Electronystagmography demonstrated slowed saccades with normal accuracy and delayed latency. The diagnosis of SCA2 was confirmed by the genetic test. Documentation of slow saccades may help differentiation among SCA subgroups.
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정규리,남정무,황선태,김병건,구자성,권오현,박종무,이정주 대한임상신경생리학회 2007 Annals of Clinical Neurophysiology Vol.9 No.2
Hashimoto’s encephalopathy has been described as a steroid-responsive syndrome of encephalopathy associated with high serum concentration of anti-thyroid antibodies. We report a 67-year-old woman who presented with myoclonus involving both upper extremities. Brain MRI and EEG showed no diagnostic abnormalities. Thyroid functions were normal, but anti-thyroid antibodies were elevated both in serum and in CSF. Hashimoto’s encephalopathy can present with myoclonus even without outstanding encephalopathic feature, therefore anti-thyroid antibody test should be included in diagnostic test in patient with myoclonus.
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2형 신경섬유종증에서 양측 소뇌다리뇌각종양으로 인한 양측 전정병증
김준엽,남정무,한정호,김지수 대한신경과학회 2010 대한신경과학회지 Vol.28 No.1
Bilateral vestibulopathy (BV) is characterized by oscillopsia and imbalance during locomotion. Half of the cases of BV are idiopathic, and BV due to brain tumor has been reported only rarely. We report a case of BV due to bilateral cerebellopontine-angle tumors in a patient with neurofibromatosis type 2. Careful history on oscillopsia and imbalance during locomotion, and regular follow-ups using the head-impulse test and dynamic visual acuity are warranted in patients with neurofibromatosis type 2.
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김병건,남정무,정규리,이정주,박종무,구자성,권오현 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.1
Background and Objectives: Patients with isolated vertigo could have central or peripheral vestibular disorders. Although some differential points exist between the two conditions, sometimes it is not easy to differentiate central vertigo from that of peripheral vestibular origin, especially in patients with isolated vertigo. We performed this study to determine the frequency of acute infarction and predictors of vertigo associated with stroke in isolated spontaneous vertigo. Materials and Methods: We prospectively evaluated 185 consecutive patients who were admitted to neurology department with acute isolated vertigo, after excluding the patients with benign paroxysmal positioning vertigo. Diffusion-weighted MRI (DWI) was obtained in 161 (87.0%) patients. Demographics, stroke risk factors, associated symptoms and signs were reviewed. Also, the locations and vascular territories of the lesions on DWI were investigated. Results: Twenty three (14.3%) patients had acute infarction on DWI. Old age and male sex were the predictors of stroke using multivariate analysis (p=0.03 and 0.02). The lesions were located in the cerebellum in 17 patients, medulla in four, and pons in another four. Cerebellar lesions were in the territory of the posterior inferior cerebellar artery in all patients. Conclusion :Isolated spontaneous vertigo may develop in posterior circulation stroke, especially in men of old age. The possibility of central origin should be considered in patients with isolated vertigo and DWI might be a good diagnostic tool.
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허혈성 뇌졸중 환자에서 몸무게에 기반한 환자 맞춤형 경정맥 헤파린 투여 지침의 유용성
장윤숙,강지훈,남정무,정규리,박종무,권오현,김병건,구자성 대한신경과학회 2007 대한신경과학회지 Vol.25 No.4
Background: Despite the lack of supporting evidence, intravenous heparin is still given frequently in the treatment of cerebral ischemia. However, there is only one study for the use of heparin nomogram in ischemic stroke or TIA. We evaluated the usefulness of a patient-specific, as well as weight-based, nomogram for the intravenous heparin in patients with ischemic stroke or TIA. Methods: From Sep. 2004 to Sep. 2005, we recruited ischemic stroke patients treated according to the specifically designed heparin nomogram. The therapeutic range (TR) of activated partial thromboplastin time (aPTT) and dose adjustment were specified as a ratio of each patient’s baseline aPTT. The first time to achieve TR (TR-time), to exceed therapeutic threshold (TE-time) and the fraction of time in TR (total time in TR/total time of heparin use, %) were analyzed. Results: A total of 45 patients were included. The mean fraction of time in TR was 72.7±14.4%. Although TR-time and TE-time did not differ according to the use of bolus injection, the fraction of first aPTT at 6 hours after start of infusion in TR was higher with bolus than without bolus (84.8 vs. 58.3, p<0.05). Conclusions: Our nomogram could achieve and maintain therapeutic heparin anticoagulation effectively. Initial bolus injection may be better to achieve therapeutic anticoagulation more rapidly. KeyWords:Anticoagulation, Heparin, Weight-based nomogram
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