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지방산 생합성효소(FabH)에 대한 Nocardia sp.대사산물의 저해효과
정동선,나여정 서울여자대학교 자연과학연구소 2004 자연과학연구논문집 Vol.16 No.-
Fatty acid biosynthesis catalyzed by the type Ⅱ fatty acid synthase (FAS) system in most bacteria but catalyzed by the type Ⅰ FAS system in mammalian. FAS may be a potential target for antibacterial drug development. We screened antibacterial substances and measured inhibitory activity on the type Ⅱ FAS (FabH) to obtain the new antibacterial substances from Actinomycetes. Nocardia sp. produced antibacterial substances after 7days of cultivation in modified glycerol medium. The metabolites exhibits a broad antibacterial spectrum, particularly potent activity against Staphylococcus eureus. The antibacterial compounds extracted from the culture broth of Nocardia sp. using ethyl acetate, and purified by silica gel column chromatography. Four fractions purified from culture broth of Nocardia sp. were measured for inhibitory activity on FabH enzyme. Two fractions (Fl and F4) showed the inhibitory activity on the type Ⅱ FAS. The structural analysis of bio-active metabolites is now under investigation.