http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Levels of common salivary protein 1 in healthy subjects and periodontal patients
Heo, Seok-Mo,Lee, Sol,Wang, HongTao,Jeong, Jeong Hyeok,Oh, Sang Wook Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.5
Purpose: Human saliva, as a vital part of the immune defense system, contains a number of distinct proteins and peptides. Recently human common salivary protein 1 (CSP1) has been identified as an abundant salivary protein and may play a role in promoting the binding of cariogenic bacteria to salivary pellicles. However, nothing else is known regarding the role of CSP1 in periodontology. The aim of this study was to quantify and compare CSP1 levels between healthy subjects and periodontal patients. Methods: This controlled clinical study was conducted in periodontally healthy individuals and patients with chronic periodontitis Chonbuk National University Hospital, with Institutional Review Board approval. Whole saliva samples were collected from 36 healthy subjects and 33 chronic periodontitis patients and analyzed. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immune blotting were conducted to ensure that anti-CSP1 monoclonal antibody (mAb) binds to CSP1 in human saliva. A sandwich enzyme-linked immunosorbent assay (ELISA) system was house-fabricated using mAb-hCSP1#14 and mAb-hCSP1#4 as a capture and a detector mAb, respectively. The CSP1 concentrations in saliva from 36 healthy subjects and 33 periodontal patients were quantified using the CSP1 sandwich ELISA system, and the results were analyzed using the Student's t-test. Results: Immunoblot analysis using mAb-hCSP1 as a probe confirmed that CSP1 in human saliva existed as a single band with a molecular weight of approximately 27-kDa. The quantification of CSP1 concentrations by CSP1 ELISA showed that the median values (25th to 75th percentiles) of periodontal patients and healthy subjects were 9,474 ng/mL (range, 8,434.10,139 ng/mL) and 8,598 ng/mL (range, 7,421.9,877 ng/mL), respectively. The Student's t-test indicated the presence of a statistically significant difference between the 2 groups (P=0.024). Conclusions: The presence of a significant difference in CSP1 levels between healthy subjects and periodontal patients suggests that CSP1 may be a potential biomarker for the detection or screening of periodontitis patients.
허석모(Seok-Mo Heo),허나래(Narae Heo) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.12
본 연구는 현상학적 방법을 적용하여 유방암 생존자들의 비약물적 추후 관리 경험에 대한 본질적 구조와 의미에 대해 심도 있게 파악하는 것을 목적으로 한다. 이번 연구에서 총 참여자는 10명으로 S시 E병원 외래에 정기적으로 내원하는 유방암 생존자로 수술, 화학요법, 방사선요법을 완료한 자들이었다. 자료수집 기간은 2014년 8월부터 2015년 2월까지로 수집된 자료는 심층면담 후 Colaizzi의 방법 적용하여 분석하였다. 연구결과, 7개의 주제와 16개의 하위범주가 도출되었다. 7개의 주제는 ‘1. 증상을 완화하기 위해 용이한 방법을 적용함, 2. 변화된 신체 상태를 위해 움직이려 함, 3. 재발 방지를 위해 특정식용 작물을 섭취함, 4. 건강을 유지하기 위한 식생활 양식이 있음, 5. 보완대체요법에 대해 항상 예의주시함, 6. 주치의 처방외 필요한 치료가 있음, 7. 자연친화적인 환경에서의 삶을 지향함’ 이었다. 이번 연구는 유방암 생존자들이 치료 후에 일상생활에서 어떻게 추후관리를 하는지 심도있게 파악하는 데 도움을 줄 것이다. 나아가 본 결과는 향후 유방암 생존자들에게 실제 관리 양식에 근거한 실행 가능한 지침과 프로그램을 제공하는데 있어 기초자료로써 제공될 것이다. The purpose of this study was to understand the essential structure and meaning of self-management intervention for breast cancer survivors by using non-pharmacological approaches. The study participants were 10 breast cancer survivors who were completing cancer treatment that involved surgery, chemotherapy, and radiation therapy. Data collected between August 2014 and February 2015 at E Hospital in S city were analyzed by using Colaizzi"s phenomenological method. Outcomes were classified into seven essential themes: 1) application of comfort measures to alleviate ongoing symptoms, 2) movement to change physical conditions, 3) special herbal intake to prevent recurrence, 4) a specially designed diet plan for health self-management, 5) constant awareness of complementary and alternative medicine, 6) unmet needs treated by one"s own doctor"s prescription, and 7) future life toward a nature-friendly environment. The study results contribute to a deeper understanding of self-management interventions in the daily lives of Korean breast cancer survivors. In addition, results provide an essential resource, based on actual self-management styles, that will help survivors to obtain guidance and participate in appropriate programs.
유방암 환자의 디스트레스가 피로에 미치는 영향: 삶의 질 매개 효과를 중심으로
허석모(Seok-Mo Heo),허나래(Narae Heo) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.9
본 연구는 유방암 환자의 디스트레스가 피로에 미치는 영향을 확인 후, 디스트레스와 피로의 관계에서 삶의 질의 매개 효과를 파악하고자 하였다. 서울시에 있는 상급종합병원 1곳에 내원한 유방암 환자를 대상으로 하였으며, 2014년 2월부터 2014년 12월까지 디스트레스, 삶의 질, 피로에 관련된 문항에 응답한 자료 110부를 분석에 사용하였다. IBM SPSS statistics 26 프로그램을 사용하여 서술통계, t-test, ANOVA, Pearson 상관관계, 위계적 회귀분석을 적용하였고, Sobel test로 삶의 질 매개 효과를 검증하였다. 삶의 질은 디스트레스(r=-.41, p <.001)와 피로(r=-.61, p <.001)와 통계적으로 각각 유의한 음의 상관관계가 있었으며, 디스트레스와 피로는 유의한 양의 상관관계(r=.53, p <.001)가 있었다. 피로에 대한 디스트레스의 직접적인 영향은 유의미했으며(β= -.337, p <.001), 삶의 질을 통한 피로에 대한 디스트레스의 간접적인 영향이 유의미했다(Sobel test: Z=3.743, p <.001). 분석 결과, 디스트레스가 피로에 미치는 영향에 있어 삶의 질이 부분 매개 효과가 있음을 확인하였다. 따라서, 유방암 환자의 디스트레스가 피로에 미치는 영향을 감소시키기 위해서, 디스트레스의 원인을 확인하고 근거기반의 심리적 지원과 삶의 질을 향상을 위한 맞춤형 지지 프로그램을 개발하여 간호 중재에 적용할 필요가 있다. The purpose of this study was to identify the mediating effect of quality of life on the impact of distress on fatigue. The subjects in this study were breast cancer patients who visited a general hospital in Seoul, and 110 of data responding to questionnaires related to distress, quality of life and fatigue were used for the analysis. Descriptive statistics, t-test, analysis of variance (ANOVA) , Pearson correlation and hierarchical regression were applied using the SPSS WIN 26 program, and the quality of life mediating effect was verified with the Sobel test. Quality of life had a significant negative correlation with distress (r=-.41, p <.001) and fatigue (r=-.61, p <.001), respectively, but distress and fatigue showed a significant positive correlation (r=.53, p <.001). The direct effect of distress on fatigue was significant (β=-.337, p <.001), and the indirect effect of distress on fatigue through the quality of life was also significant (Sobel test: Z=3.743, p <.001). It was confirmed that the quality of life had a partial mediating effect on the influence of distress on fatigue. In order to reduce the effect of distress on fatigue in breast cancer patients, it is necessary to identify the causes of distress. A personalized support program should be developed, which can improve the patient’s evidence-based psychological support and quality of life for applying nursing interventions.
Interleaved 승압형 역률 전치보상 컨버터의 해석 및 제어기 설계
허태원,최선필,노태균,안인모,박한석,우정인 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.10 No.1
In this paper, interleaved boost converter is applied as a pre-regulator in switch mode power supply. Interleaved Boost Power Factor Preregulator(IBPFP) can reduce input current ripple as a simple voltage control loop only without inner current loop, because input current is divided each 50% by two switching devices. IBPFP can be classified as three cases from duty ratio condition in continuous current mode and be carried out state space averaging small signal modeling. According to modeling, the PID controller is applied and voltage control loop is constructed for suitable design condition. From frequency domain analysis, it is verified that control system is satisfied with design condition of switch mode power supply.