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RISS 인기검색어
- 검색키워드
- 저자 : ( Nigel H. Kyle ) (검색결과 1 건)
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( Natalya E. Chalyk ),( Tatiana Y. Bandaletova ),( Nigel H. Kyle ),( Ivan M. Petyaev ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4
Background: Problems of skin aging and its prevention cur-rently attract increasing attention with the growth of human life expectancy. The morphology of the stratum corneum (SC) is well known, but investigation of age-related changes of its structure is difficult in the absence of non-invasive sam-pling methods. The residual skin surface components (RSSC) that overlay the SC can be easily collected non-invasively. Objective: The aim of this study was to examine morphology of RSSC samples collected from the surface of facial skin of healthy female volunteers of different age. Methods: RSSC samples were non-invasively collected from 53 adult female volunteers (22 aged in the range 18∼25 years and 31 aged in the range 50∼73 years). The samples were analysed microscopically. Results: Distinct age-related changes were determined for lipid droplet size, corneocyte desquamation level and lipid crystal count. There was a significant (p=0.0006) decrease in lipid droplet size among older women. Similarly, significantly (p=0.0401) lower lipid crys-tal numbers were present in the older group. Conversely, cor-neocyte desquamation was significantly higher (p=0.0007) in older women. No age-related difference in microbial pres-ence in the RSSC could be detected. Result patterns were generally similar to those previously found in male volun-teers; however gender-related differences in the absolute val-ues were revealed. Conclusion: Non-invasively collected RSSC samples allow identifying age-related changes on fa-cial skin surface. The results of this study highlight gender-de-pendence of distinct elements of age-associated impairment of epidermal barrier and can be employed for developing new approaches to prevent changes associated with skin aging. (Ann Dermatol 29(4) 454∼461, 2017)
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