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RISS 인기검색어
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- 저자 : ( Naoki Shimojo ) (검색결과 1 건)
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Intestinal Microbiota and the Development of Allergy in Infants
( Yoichi Kohno ),( Shuichi Suzuki ),( Eduardo Campos ),( Naoki Shimojo ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
We analyzed fecal microbiota in Japanese infants with or without allergy at 6 months using a culture technique. Determination of allergy was based on clinical symptoms, signs, and skin prick test. There were no differences in frequencies or counts of 13 genera and yeast-like organisms at 6 months of age between allergic and non-allergic infants. Bifidobacterium was dominant in all infants irrespective of the presence or absence of allergy. We next investigated the composition of fecal Bifidobacterium species in allergic and non-allergic infants using Bifidobacterium species-specific or group- specific primers based on 16S rDNA sequences at 1, 3 and 6 months of age. At 1 month of age, allergic infants had a higher prevalence of B. catenulatum than non-allergic infants (60.0% vs. 6.3%, P<0.01). At 6 months of age, allergic infants had a higher prevalence of B. bifidum than non-allergic infants (70.0% vs. 12.5%, P<0.01). These differences were not related to feeding methods. Finally, we studied the activity of B. bifidum in comparison with B. adolescentis to induce TNF-α and IL-10 from cord blood mononuclear cells. The results suggest B. bifidum has lower activity to induce both cytokines compared to B. adolescentis, suggesting that colonization of lower cytokine producing Bifidobacterium species or strains may be a risk factor for the development of allergy in infancy. (Korean J Asthma Allergy Clin Immunol 2007;27:220-225)
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