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RISS 인기검색어
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- 저자 : ( Meilin Zhu ) (검색결과 3 건)
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Anionic defect engineering of transition metal oxides for oxygen reduction and evolution reactions
Zhu, Yunmin,Liu, Xi,Jin, Shiguang,Chen, Huijun,Lee, Wonyoung,Liu, Meilin,Chen, Yan The Royal Society of Chemistry 2019 Journal of materials chemistry. A, Materials for e Vol.7 No.11
<P>The development of cost-effective catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial for enhancing the energy efficiency of many electrochemical energy conversion and storage devices. Owing to their low cost and high activity, transition metal oxides have attracted much attention as alternative electrocatalysts to replace the currently used noble metal-based catalysts. Anion defects (<I>e.g.</I>, oxygen vacancies, interstitials, and anion dopants) can significantly change the electronic structure of oxides or the stability of adsorbed intermediates, thus greatly enhancing the electrocatalytic activities of the oxide surface. Anionic defect engineering represents a potential new direction for rational design of high-performance electrocatalysts. In this review, recent progress in manipulating the anion defects in transition metal oxides for enhancing their activity and stability is summarized and the proposed mechanisms for enhanced performance are discussed in detail. Challenges and prospects are also discussed in the development of a new generation of highly efficient ORR and OER electrocatalysts.</P>
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Zhu, Mengyuan,Zhao, Meilin,Hu, Bo,Wang, Yunji,Li, Yao,Song, Jinlin Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.3
Purpose: This systematic review and meta-analysis was conducted to assess the effects of glycine powder air-polishing (GPAP) in patients during supportive periodontal therapy (SPT) compared to hand instrumentation and ultrasonic scaling. Methods: The authors searched for randomized clinical trials in 8 electronic databases for relevant studies through November 15, 2019. The eligibility criteria were as follows: population, patients with chronic periodontitis undergoing SPT; intervention and comparison, patients treated by GPAP with a standard/nozzle type jet or mechanical instrumentation; and outcomes, bleeding on probing (BOP), patient discomfort/pain (assessed by a visual analogue scale [VAS]), probing depth (PD), gingival recession (Rec), plaque index (PI), clinical attachment level (CAL), gingival epithelium score, and subgingival bacteria count. After extracting the data and assessing the risk of bias, the authors performed the meta-analysis. Results: In total, 17 studies were included in this study. The difference of means for BOP in patients who received GPAP was lower (difference of means: -8.02%; 95% confidence interval [CI], -12.10% to -3.95%; P<0.00001; I<sup>2</sup>=10%) than that in patients treated with hand instrumentation. The results of patient discomfort/pain measured by a VAS (difference of means: -1.48, 95% CI, -1.90 to -1.06; P<0.001; I<sup>2</sup>=83%) indicated that treatment with GPAP might be less painful than ultrasonic scaling. The results of PD, Rec, PI, and CAL showed that GPAP had no advantage over hand instrumentation or ultrasonic scaling. Conclusions: The findings of this study suggest that GPAP may alleviate gingival inflammation more effectively and be less painful than traditional methods, which makes it a promising alternative for dental clinical use. With regards to PD, Rec, PI, and CAL, there was insufficient evidence to support a difference among GPAP, hand instrumentation, and ultrasonic scaling. Higher-quality studies are still needed to assess the effects of GPAP.
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Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines
( Yu-ru Zhao ),( Hong-mei Li ),( Meilin Zhu ),( Jing Li ),( Tao Ma ),( Qiang Huo ),( Young-soo Hong ),( Cheng-zhu Wu ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.4
Heat shock protein 90 (Hsp90) is treated as a molecular therapeutic target for the prevention and treatment of cancer. Geldanamycin (GA) was the first identified natural Hsp90 inhibitor, but hepatotoxicity has limited its clinical application. Nevertheless, a new GA analog (WK-88- 1) with the non-benzoquinone skeleton, obtained from genetically engineered Streptomyces hygroscopicus, was found to have anticancer activity against two human breast cancer cell lines. WK-88-1 produced concentration-dependent inhibition of cell proliferation, cell cycle arrest, and apoptosis in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 cell lines. Detailed analysis showed that WK-88-1 downregulated some key cell cycle molecules (CDK1 and cyclin B1) and lead to G2/M cell cycle arrest. Further studies also showed that WK- 88-1 could induce human breast cancer cell apoptosis by downregulating Hsp90 client proteins (Akt, p-Akt, IKK, c-Raf, and Bcl-2), decreasing the ATP level, increasing reactive oxygen species production, and lowering the mitochondrial membrane potential. Meanwhile, we discovered that WK-88-1 significantly decreased the levels of Her-2 and ER-α in MCF-7 cells but not in MDA-MB-231 cells. In addition, WK-88-1 significantly increased caspase-3, -8, and -9 activities and the cleavage of PARP in a concentration-dependent manner (with the exception of caspase-3 and PARP in MCF-7 cells). Taken together, our preliminary results suggest that WK-88-1 has the potential to play a role in breast cancer therapy.
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