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- 저자 : ( Manisha Sinha ) (검색결과 1 건)
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Rejuvenation of Aged Skeletal Muscle by Systematic Factor, GDF11
( Young C. Jang ),( Manisha Sinha ),( Amy J. Wagers ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: Recent studies involving heterochronic parabiosis indicate that impaired skeletal muscle regeneration in aged animals is in part systemically controlled and reversible by exposure to a young circulation. While prior studies have identified a handful of systemic "aging" factors, discovery of the humoral "rejuvenating" factors that act on muscle stem cells (satellite cells) to restore regenerative function has been relatively more elusive. Here, we demonstrate that the circulating hormone Growth Differentiation Factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Methods: Using either heterochronic parabiosis (young and aged mice with shared circulation) or systemic delivery of recombinant GDF11 (0.1 mg/KG), in vitro and in vivo muscle stem cell function, regenerative potential, as well as overall muscle function were assessed. Results: Supplementation of systemic GDF11 levels, which normally decline with age, is sufficient to reverse functional impairments and restore genomic integrity in skeletal muscle stem cells. Augmentation of GDF11 levels further improved structural and functional features of resting skeletal muscle, resulting in increased strength and enhanced endurance exercise capacity. Conclusion: Taken together, these data reveal critical mechanisms in the systemic regulation of aging and identify a promising candidate therapeutic for the reversal of age-related skeletal muscle and stem cell dysfunction.
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