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Jean Paul Dzoyem,Antoine H. L. Nkuete,Barthelemy Ngameni,Jacobus N. Eloff 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
This study was aimed at investigating the antiinflammatoryand anticholinesterase activity of six naturallyoccurring flavonoids: (2) pinostrobin (1), 20,40-dihydroxy-30,60-dimethoxychalcone (2), 6-8-diprenyleriodictyol (3),isobavachalcone (4), 4-hydroxylonchocarpin (5) and6-prenylapigenin (6). These compounds were isolated fromDorstenia and Polygonum species used traditionally to treatpain. The anti-inflammatory activity was determined by usingthe Griess assay and the 15-lipoxygenase inhibitory activitywas determined with the ferrous oxidation-xylenolorange assay. Acetylcholinesterase inhibition was determinedby the Ellman’s method. At the lowest concentrationtested (3.12 lg/ml), compounds 2, 3 and 4 had significantNO inhibitory activity with 90.71, 84.65 and 79.57 % inhibitionrespectively compared to the positive controlquercetin (67.93 %). At this concentration there was nosignificant cytotoxicity against macrophages with 91.67,72.86 and 70.86 % cell viability respectively, compared to73.1 % for quercetin. Compound 4 had the most potentlipoxygenase inhibitory activity (IC50 of 25.92 lg/ml). Withthe exception of (2) pinostrobin (1), all the flavonoids hadselective anticholinesterase activity with IC50 values rangingbetween 5.93 and 8.76 lg/ml compared to the IC50 4.94 lg/ml of eserine the positive control. These results indicate thatthe studied flavonoids especially isobavachalcone are potentialanti-inflammatory natural products that may have thepotential to be developed as therapeutic agents against inflammatoryconditions and even Alzheimer’s disease.
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( Sandra Poncet ),( Jean Barthelemy ) 세종대학교 경제통합연구소 (구 세종대학교 국제경제연구소) 2008 Journal of Economic Integration Vol.23 No.4
This paper documents business cycles` fluctuations in Chinese provinces. China`s de facto federalism, within a context of great geographical and economic diversity, suggests the great importance of policy coordination between provinces. We investigate the role of various potential determinants of provincial business cycles` synchronization. We consider exogenous factors like distance and size as well as policy factors such as industrial, fiscal and trade policy. Results emphasize the benefits of domestic trade and local fiscal policy rationalization on the stabilization of output fluctuations. However, they also identify international trade and local economic policy heterogeneity as growing centrifugal forces.
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