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- 저자 : ( Binglin Wu ) (검색결과 3 건)
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Wu Ya,Tan Fang,Zhang Tianyu,Xie Binglin,Ran Lixian,Zhao Xin 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5
Lotus leaves (Nelumbo nucifera) are widely used in medicines and foods. The investigate systematically studied the anti-obesity effect of lotus leaf extracts. It could reduce body weight, alleviate liver damage, and inhibit fat accumulation in high-fat-diet-induced obese mice. Lotus leaf extracts reduced serum alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (AKP) levels; decreased total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels in the serum; and increased high-density lipoprotein cholesterol (HDL-C) levels to improve dyslipidemia. Lotus leaves also inhibited inflammation accompanied by obesity via decreasing inflammatory cytokine interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ), and IL-6 levels and increasing anti-inflammatory cytokine IL-4 and IL-10 levels. qPCR analysis revealed that lotus leaves upregulated peroxisome proliferator-activated receptor alpha (PPAR-α), lipoprotein lipase (LPL), carnitine palmitoyltransferase 1 (CPT1), and cholesterol 7 alpha hydroxylase (CYP7A1) mRNA expressions and downregulated peroxisome proliferator- activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding protein alpha (C/EBP-α) mRNA expressions, to reduce adipocyte differentiation and fat accumulation, promote oxidation of fat and decomposition of triglyceride and cholesterol. So, lotus leaves effectively regulated lipid metabolism, alleviated inflammation and liver injury in obese mice; thus, lotus leaves could be further developed as a food to combat obesity.
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T-START: Time, Status and Region Aware Taxi Mobility Model for Metropolis
( Haiquan Wang ),( Shuo Lei ),( Binglin Wu ),( Yilin Li ),( Bowen Du ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.7
The mobility model is one of the most important factors that impacts the evaluation of any transportation vehicular networking protocols via simulations. However, to obtain a realistic mobility model in the dynamic urban environment is a very challenging task. Several studies extract mobility models from large-scale real data sets (mostly taxi GPS data) in recent years, but they do not consider the statuses of taxi, which is an important factor affected taxi’s mobility. In this paper, we discover three simple observations related to the taxi statuses via mining of real taxi trajectories: (1) the behavior of taxi will be influenced by the statuses, (2) the macroscopic movement is related with different geographic features in corresponding status, and (3) the taxi load/drop events are varied with time period. Based on these three observations, a novel taxi mobility model (T-START) is proposed with respect to taxi statuses, geographic region and time period. The simulation results illustrate that proposed mobility model has a good approximation with reality in trajectory samples and distribution of nodes in four typical time periods.
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Yang Lei,Xing Binglin,Wang Likui,Yuan Linlin,Manzoor Mujahid,Li Fen,Wu Shaoying 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.4
In insects, proteolytic cascades medicated by serine proteases (SPs), serine protease homologs (SPHs) and prophenoloxidases (PPOs) control several physiological processes, notably the innate immunity. However, no attempts have been made to identify and characterize these genes in Spodoptera frugiperda, one of the most destructive agricultural pests. In this study, 83 SPs, 26 SPHs and four PPOs were respectively identified in S. frugiperda genome based on homology blast against those of other insects. We then analyzed the domain organization of these proteins and assigned them into different groups by phylogenetic reconstruction. Furthermore, the mRNA levels of clip-domain SPs/SPHs (cSPs/cSPHs) and PPOs were quantified in response to a mixed infection of Micrococcus luteus and Escherichia coli, and obvious accumulations were recorded in immune tissues, including hemocytes and fat body. In the latter study, we profiled the expression patterns of highly expressed cSPs and PPOs in different developmental stages, including egg, larva, pupa, female and male adults. It was shown that most cSPs were abundantly expressed in adults, while PPOs were detected at high levels in both egg and larval stages. These current findings substantially add to our understanding of the roles of S. frugiperda SPs, SPHs and PPOs in immune regulation and further lay a solid foundation for uncovering the interaction mechanisms between insects and pathogens.
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