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RISS 인기검색어
- 검색키워드
- 저자 : SHUKLA NUTAN RAKESHKUMAR (검색결과 1 건)
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Development of Drug delivery Systems for Combination Therapy Using GNRs Contained Nanoplatform
SHUKLA NUTAN RAKESHKUMAR Convergence Science, Sahmyook university 2023 국내박사
Multimodal approaches combined with various nanomaterials and advanced techniques have been developed for synergistic cancer treatment. Among various therapies, conventional chemotherapy (CHT) is one of the direct and certain cancer treatments that compromise unintended effects due to non-specific action on both tumor and normal cells whereas, patient-friendly photothermal therapy (PTT) has the possibility to treat embedded tumors in vital regions with its minimal invasion, though it does not guarantee complete removal of cancers. On the other hand, the combination of CHT-PTT enables to the provision of a promising tool for direct cancer treatment with minimal side effects. In this regard, nanostructured materials such as gold nanorods (GNRs) with tuned size and surface characteristics are the key components and are designed to enhance heating capacity and deliver drugs actively or passively at the tumor site. In this review, we summarize the pioneering work done in the synergism of CHT and PTT and provide the current state of the art in the development of inorganic and organic nanocomposites for combinational therapy. Upon near-infrared (NIR) irradiation, combined treatment comprising of photothermal therapy (PTT) and chemotherapy (CHT) offers synergistic effects by inducing localized heat to intended tumor sites and simultaneously allowed delivering drugs thus minimizing undesired side-effects but enhances cytotoxic therapies. In this study, we developed a novel platform that enables simultaneously to respond light stimuli with localized heat and released drugs using drug contained gold nanorods (GNRs). Methotrexate (MTX), a model anticancer drug is attached through hydrolytic ester bonding to targeting molecular hyaluronic acid (HA) that is coated onto GNRs. Based on the rationale, HA provides a good scaffold for high biocompatibility to shield risky GNRs, targeting for a CD44 receptor, and easy chemical binding of drugs. Upon a single light irradiation, MTX-HA functionalized GNRs (MTX-HA @GNRs) provide localized heat to cancer areas for PTT and the elevated temperature accelerates hydrolytic cleavage of the ester bond onto GNRs in physiological condition for CHT, ultimately releasing MTX to cells. In contrast to previous combination therapies that do not concurrently offer heat and drugs upon light stimuli, our NIR triggered CHT with PTT provides clinically effective options with combinatorial treatment that possesses high efficacy resulted in in vitro tests. Nobel metals, especially gold based nanorods (GNRs) complexed with amphiphilic polymers, have gained attention in combination treatments consisting of photothermal therapy (PTT) and chemotherapy (CHT). Such nanano scscaffolds haveehave en recognized as excellent nanocarriers (NC) for the encapsulation of hydrophobic and hydrophilic molecules. GNRs provide synergistic effects by inducing localized cytotoxic heat and drug release in response to near-infrared irradiation (NIR). Because of this w,e concentrated on miniaturizing ofart nanoplatforms by agitating GNRs with pre-synthesized amphiphilic PP (PPEG) and PPFA (PPEG-Folic acid). These novel nanostructures, called PP-GNRs and PPFA-GNRs, enabled the substantial loading of hydrophobic substances such moas del drug (Nile red) and anticancer medications paclitaxel (PTX). The physical encapsulation preserved the PTX's action and exerted three distinct effects: first, passive targeting using enhanced permeability (EPR) and second, active targeting using FA receptor and third, regulated drug release by leveraging the plasmonic feature of GNRs in the presence of NIR. Contrarily, CHT-PTT outperforms individual thermo- or chemotherapies, and the findings imply that GNRs may be a potential nanocarrier for the delivery of hydrophobic medicines in various cancer microenvironments. Although persistent infection from chronic wound lowers the efficacy of single therapy; But combination therapy with prolonged drug release have shown promising effect, such as elimination of heavy bacterial film and multi/single drug resistance with minimal side effects. One such breakthrough is multilayered scaffold that are chemically and physiologically stable. To achieve this objective, we demonstrated construction of layer-by-layer (LBL) assembly aligned by alternate deposition of (PEI/PSS and PAA/PSS) based on electrostatic force. These films exhibited loading of IBU and gen which can be altered depending on different parameter such dipping time, pH and number of layers. Briefly, gen was encapsulated onto PPGNRs, as GNRs have good stability and their antibacterial properties can be enhanced by tuning surface upon adding chemical drugs. Such functionalized GNRs showed excellent photo thermal property which assisted controlled release of gen via deconstruction of thin layers, whereas burst release of IBU. Furthermore, complete disruption of bacterial colonies when combined with near infrared irradiation (NIR).The formed LBL endowed the great healing capability, controlled antibiotic release solve the problems of bacterial resistance due to synergistic effect. Taken together, the antibacterial, cytocompatibility, and stimuli responsive characteristics of this robust multilayer assembly can be promising multifunctional drug delivery system in different medical aliments.
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