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RISS 인기검색어
- 검색키워드
- 저자 : Romero-Ramirez, Edwar (검색결과 4 건)
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Ramirez-Romero, Rafael Iowa State University 2000 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
The objective of this work was to determine the numbers of stained mast cells (MCs) and substance P (SP) immunoreactivity during the initiation and progression of pulmonary lesions in a model of pneumonic pasteurellosis (PP) in ruminants. The first experiment demonstrated that, at 6 h after intrabronchial deposition of <italic>Mannheimia</italic> (<italic>Pasteurella</italic>) <italic> haemolytica</italic> in neonatal calves, MC numbers decreased in sites of severe lung damage. Prior administration of a sialyl Lewis mimetic (TBC1269) intended to prevent neutrophil infiltration had no effect on MC numbers, suggesting that MC degranulation is unaffected by selectin inhibition. In the second study, a single high dose of dihydrocapsaicin (DHC) administered to neonatal lambs depleted peptidergic nerves of SP. Depletion was measured in nasal septum, the site richest in SP fibers, and was estimated to be 85% of controls. In the upper and lower respiratory tract MCs density increased progressively with age, from 3 to 21 days, but DHC-treated animals had significantly higher numbers of MCs; this suggests a functional association between MCs and SP fibers. Histamine content in the lung was similar to controls. The model is suitable for studies of the inflammatory response in the respiratory tract when the neurogenic contribution is reduced. In the third experiment, diminished numbers of MCs and histamine during the acute phase (1 day) of PP in sheep were associated with SP immunoreactivity in macrophages infiltrating the areas of severe damage, suggesting an extraneural source of SP. At 15 days, MCs were scarce at sites with pyogranulomatous foci, but increased in areas with interstitial pneumonia. Substance P immunoreactivity demonstrated that not only an extrinsic sensory innervation, but also an intrinsic contribution of pulmonary ganglion neurons, sustain the inflammatory response. At 45 days the fibroplastic changes in pleura, interlobular spaces, and interstitium were marked, as was the presence of bronchiolitis obliterans. These changes were associated with an increased number of MCs; however, the elevation in histamine did not correspond with the MCs increment. In areas of severe fibrosis SP immunoreactivity in nerve fibers was mild suggesting that the absence of SP during chronic PP hinders tissue repair.
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Romero-Ramirez, Maria The University of Wisconsin - Madison 2009 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
The demographic makeup of the United States is becoming increasingly racially and ethnically diverse. Approximately one third of U.S. citizens are non-European Americans and more than 32 million individuals speak a language other than English. People from racial and ethnic minority backgrounds are reported to have higher rates of work injury, disability, and unemployment than European Americans. Specifically, traumatic brain injury (TBI) has been reported to occur at higher rates for African Americans and Hispanic Americans. Individuals with TBI, as a whole, experience many difficulties in returning to work and turn to the state vocational rehabilitation (VR) system as a viable source to obtain employment. Rehabilitation counselors are beginning to work with an increasingly larger number of clients with TBI from racial and ethnic minority backgrounds with traumatic brain injury. Concerns about the detrimental effects of racial and ethnic bias affecting acceptance rates, service delivery, and employment outcomes among individuals from racial and ethnic minority groups have been identified in the rehabilitation literature. This research project examines VR service patterns and employment outcomes for racial and ethnic minority individuals with TBI. Using the Rehabilitation Services Administration National Case Services Reprort (RSA-911) fiscal year (FY) 2007; several analyses are conducted to examine if there are differences in services provided for different racial and ethnic groups and the likelihood of them obtaining competitive employment compared to European American clients. Descriptive statistics, multiple discriminant analysis, odds ratios, and several logistic regressions are used for the current study. Findings indicate that there are service pattern differences for clients with TBI from racial and ethnic minority groups especially between European Americans and African Americans. Further, results indicate that differences in employment outcomes also exist between the racial and ethnic minority groups. Implications for more rigorous studies to examine the effects of stereotypes, AODA assessment competencies, and assessment of functional abilities for rehabilitation counselors for all racial and ethnic minority clients with TBI were identified.
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