흰쥐에 있어서 Polychlorinated biphenyl의 亞急性 毒性에 미치는 Glutathione의 影響 = Influences of glutathione on the subchronic toxicity of polychlorinated biphenyl in rats

다국어 초록 (Multilingual Abstract)

This study was attempted to investigate the effect of glutathione on subacute toxicity of the rat evoked by PCB(polychlorinated biphenyl) which is presently used as an insulating material in various fields of the industry.
Experimental results obtained from the present study are as the following ;
1) PCB produced dose- related decrased body weight and glutathione along with the increased serum glutamic pyruvic transaminase, alkaline phosphatase, serum triglyceride,cytochrome P450, and also increased the weight of liver, spleen, kidney and thymus to body weight by comparing with the corresponding control group.
2 ) The combined medication of PCB and cysteine which is known as a precursor of glutathione, made the improvement of these effects induced by a single administration of PCB.
3) The treatment of PCB with diethyl maleate, a depletor of glutathione in hepatic tissues, did exaggerate PCB- induced toxic effects.
These experimental data suggest that PCB causes toxic effects mediated by its metabolites produced by microsomal enzymes in he patic cells, and that these toxicities may be closely related to glutathione levels in liver.

목차 (Table of Contents)

• 목차 = 1
• ABSTRACT = 3
• Ⅰ. 序論 = 5
• Ⅱ. 實驗 = 8
• Ⅲ. 結果 = 13
• 1. 體重 및 臟器에 대한 影響 = 13
• 2. Serum glutamic pyruvic transaminase 및 alkaline phosphatase에 대한 影響 = 16
• 3. s-Triglyceride와 blood urea nitrogen에 대한 影響 = 19
• 4. Cytochrome P450과 glutathione에 대한 影響 = 21
• Ⅳ. 考察 = 25
• Ⅴ. 結論 = 29
• REFERENCES = 30