Autophagy Biomarkers in Patients with Acute Myocardial Infarction = 급성심근경색 환자에서의 자가포식 바이오마커 연구

다국어 초록 (Multilingual Abstract)

This study was conducted to investigate whether autophagy-related biomarkers are elevated in patients with acute myocardial infarction (AMI) and to evaluate the association between biomarkers related to autophagy and apoptosis and clinical prognosis.
Patients diagnosed with AMI were compared with a control group without significant coronary artery stenosis. The results demonstrated that, regardless of the sampling site, circulating levels of autophagy- and apoptosis-related biomarkers were significantly higher in patients with AMI than in controls. Among these biomarkers, Beclin1 showed the strongest association with angiographic disease severity and clinical outcomes. In addition, coronary LC3-II levels were positively correlated with infarct size as assessed by single-photon emission computed tomography (SPECT).
These findings suggest a close relationship between autophagy-related biomarkers and AMI and indicate their potential utility as prognostic indicators in patients with acute myocardial infarction.

목차 (Table of Contents)

• 1. Introduction 1
• 2. Method 3
• 2.1 Study design
• 2.2 Study participants
• 2.3 Protocol
• 2.4 Statistical analysis
• 3. Results 7
• 3.1 Baseline characteristics
• 3.2 Pre-PCI Autophagy and Apoptosis activity
• 3.3 Comparison of Autophagy and Apoptosis Biomarkers Based on Angiographic characteristics
• 3.4 Correlation between Autophagy and Apoptosis Biomarkers with SPECT results in AMI patients
• 3.5 Biomarker and Major Adverse Cardiovascular Events (MACE)
• 4. Discussion 28
• 4.1 Increased Autophagy and Apoptosis Activity in AMI Patients
• 4.2 Association between Autophagy Activity with Clinical Outcomes
• 4.3 Relationship Between Autophagy Activity and Infarct Size
• 4.4 Study limitations
• 5. Conclusion 32
• References 33
• Korean Abstract 36