Photothermal immunotherapy using liposomes assembled with CuS core = 황화 구리 코어로 조립된 리포좀을 이용한 광열 면역 치료

다국어 초록 (Multilingual Abstract)

Various new technologies for cancer treatment are being developed, but there are still limitations in blocking metastasis and recurrence. Therefore, there is a growing need for therapeutics that block metastasis and recurrence. In this study, we developed a therapeutic strategy that combines photothermal therapy (PTT) with immunotherapy to induce local tumor elimination and induce immune responses. Copper-based materials are gaining attention as new tumor therapeutics by the function of that they can perform PTT against tumors. We prepared an immune stimulator monophosphoryl lipid A (MPLA) containing liposomes assembled with copper sulfide (CuS), which is named CM-lipo. CM-lipo formed a novel morphology as three to four liposomes assembled with CuS core and showed absorbance at near 980 nm and responded to 980 nm near-infrared (NIR) laser. Upon 980 nm NIR laser irradiation after CM-lipo treatment, apoptosis both in vitro and in vivo in CT-26 tumor cells and activation of dendritic cells (DCs) were induced. Furthermore, mice whose primary tumors had been completely eliminated by CM-lipo prevented the growth of second challenged metastatic lung cancer growth. This was examined that CT-26 tumor antigen-specific T cells response induced by DC activation. Therefore, CM-lipo not only eradicates primary tumors by PTT but also prevents metastasis and recurrence cancer.

목차 (Table of Contents)

• Abstract Ⅰ
• List of Figures Ⅲ
• List of Abbreviations Ⅳ
• Introduction 1
• Results 3
• Discussion 20
• Conclusion 22
• Materials and Methods 23
• Reference 27
• Abstract in Korean 30