개 고지혈증 관리의 약물–영양 통합 접근: 라우르산·피브레이트 치료의 전임상·임상적 평가 = Integrated Pharmacologic–Nutritional Strategy for Canine Hyperlipidemia: A Preclinical and Clinical Assessment of Lauric Acid and Fibrate Therapies

다국어 초록 (Multilingual Abstract)

This study integrates clinical and preclinical information to formulate a strategy for the management of hyperlipidemia in dogs, utilizing a mix of pharmaceutical intervention and continuous dietary lipid management. Chapter 1 discusses dogs who had naturally high levels of lipids and were given fibrates (bezafibrate or fenofibrate), either with or without low-fat diets. It demonstrates that triglyceride levels declined rapidly and markedly after therapy started. Cholesterol levels moved less, while liver and kidney indices remained stable over the monitoring period. This backs up short-term tolerability. Chapter 2 presents an evaluation of black soldier fly larvae (BSFL) oil enhanced with lauric acid in mice fed diets containing different inclusion levels. There were no symptoms of liver damage, kidney difficulties, or growth concerns, thus the oil is safe to use in the examined settings. Chapter 3 uses these results to help with future feeding trials of BSFL-based meals for dogs. The dogs' body weight and feces quality stayed the same, and their blood and biochemical levels stayed within normal ranges, thus the feeds were palatable and well tolerated.
This study shows that fibrate medication, when combined with a low-fat diet when needed, works well to control triglyceride levels in dogs. It also reveals that lauric lipids from BSFL are a safe and long-lasting source of nutrition that should be evaluated for usage in animals with dyslipidemia. This connects short-term care for patients with long-term improvements in the diet of dogs.

목차 (Table of Contents)

• Abstract 1
• General Introduction 3
• General Introduction 4
• References 7
• Chapter I. Comparative Effectiveness of Lipid-Lowering Interventions in Canine Hyperlipidemia: A Retrospective Study 10
• Introduction 11
• Materials and Methods 14
• Results 16
• Discussion 34
• Conclusion 40
• References 42
• Chapter II. Biochemical and Histological Safety Evaluation of Lauric Acid-Enriched Functional Diets in Rodent Models 45
• Introduction 46
• Trial 1: Safety Assessment of Lauric Acid-Enriched Diet in Healthy Mice 50
• Materials and Methods 50
• Results 52
• Trial 2: Functional Evaluation of Lauric Acid-Enriched Diet in Diet -Induced Obese Mice 56
• Materials and Methods 56
• Results 59
• Discussion 66
• Conclusion 75
• References 77
• Chapter III. Translational Assessment of Lauric Acid-Enriched Functional Diets in Normal and Obese Canine Models of Hyperlipidemia 81
• Introduction 82
• Trial 1: Subchronic Safety and Tolerability Evaluation of a Lauric AcidEnriched Functional Diet in Healthy Dogs 85
• Materials and Methods 85
• Results 88
• Trial 2: Functional Evaluation of Lauric Acid-Enriched Diet in Dogs with Dyslipidemia 96
• Materials and Methods 96
• Results 98
• Discussion 105
• Conclusion 110
• References 111
• General Conclusion 115
• General Conclusion 116
• References 118
• 국문 초록 120