전립선증식증 수술 환자에 대한 저령탕의 효과와 안전성 : 체계적 문헌고찰과 메타분석

다국어 초록 (Multilingual Abstract)

Objective :
The aim of this study was to evaluate the efficacy and safety of Jeoryeong-tang in patients who underwent surgery for benign prostatic hyperplasia(BPH), using a systematic review and meta-analysis.
Methods :
A systematic search was conducted in 10 electronic databases to identify randomized controlled trials evaluating Jeoryeong-tang in postoperative BPH patients. Two independent researchers performed study selection, data extraction, and risk-of-bias assessment. Meta-analysis was performed using mean differences or risk ratios with 95% confidence intervals.
Results :
Six randomized controlled trials published in China were included, comprising 507 participants. Jeoryeong-tang was most commonly administered as decoction monotherapy for 1–4 weeks. Meta-analysis showed that Jeoryeong-tang significantly improved maximum urinary flow rate (Qmax) compared with control treatment, whereas residual urine volume (RUV) did not differ significantly. In subgroup analysis according to surgical type, a significant improvement in Qmax was observed in the TURP subgroup, while the TUVP subgroup did not show a statistically significant difference. Studies reporting complications suggested that urinary incontinence, secondary bleeding, and TUR syndrome tended to occur less frequently in Jeoryeong-tang groups than in controls.
Conclusion :
This systematic review and meta-analysis suggest that Jeoryeong-tang may be effective and safe for improving postoperative urinary symptoms and recovery in patients after BPH surgery, with possible variation in treatment response according to surgical method. These findings provide supplementary evidence to support the postoperative use of Jeoryeong-tang; however, the limited number and methodological quality of the included trials reduce the certainty of evidence. Large-scale, well-designed randomized controlled trials are required to confirm these results.

목차 (Table of Contents)

• 목 차 ⅰ
• 표 목 차 ⅳ
• 그림목차 ⅴ
• Ⅰ. 서 론 01
• Ⅱ. 연구 방법 03
• 1. 연구대상 선정 및 배제 기준 03
• 1) 연구 대상(Participants) 03
• 2) 중재 방식(Interventions) 03
• 3) 비교 중재(Comparisons) 03
• 4) 중재 결과(Outcomes) 04
• 5) 연구 설계(Study Designs) 04
• 2. 문헌 검색 05
• 3. 자료 선별 06
• 4. 자료 추출 06
• 5. 비뚤림 위험 평가 07
• 6. 메타분석 08
• Ⅲ. 결 과 09
• 1. 문헌 선정 09
• 2. 자료 분석 11
• 1) 문헌 정보 11
• 2) 연구 대상 11
• 3) 중재 치료방법 분석 13
• (1) 치료 방법 특성 13
• (2) 치료 기간 13
• (3) 저령탕의 1일 복용 횟수 13
• (4) 저령탕의 제형 13
• (5) 저령탕의 약재 구성 14
• 4) 대조 치료방법 분석 19
• 5) 평가 지표 분석 19
• 6) 치료 효과 분석 20
• (1) 저령탕 vs 관찰군 20
• (2) 저령탕 vs 약물군 20
• (3) 저령탕+간호요법 vs 간호요법 21
• 7) 안전성 및 탈락자 보고 분석 21
• 3. 비뚤림 위험 평가 25
• 1) 무작위 배정과정에서 발생하는 비뚤림 25
• 2) 의도한 중재에서 이탈로 인한 비뚤림 25
• 3) 중재결과 자료의 결측으로 인한 비뚤림 25
• 4) 중재결과 측정의 비뚤림 26
• 5) 보고된 연구결과 선택의 비뚤림 26
• 4. 메타분석 27
• 1) 저령탕 vs 관찰군 27
• (1) Qmax 27
• (2) RUV 28
• Ⅳ. 고 찰 30
• Ⅴ. 결 론 36
• 참 고 문 헌 36
• 영 문 초 록 42
• 부 록 44
• 감 사 의 글 48