코로나바이러스 감염증 2019(COVID- 19) 완화를 위한 소독제의 안전성 평가 = Assessing the Safety of Disinfectants in Mitigating Coronavirus Disease 2019

다국어 초록 (Multilingual Abstract)

Objectives: Amidst the COVID-19 pandemic, disinfectants have played a pivotal role in controlling the transmission of the disease, employed for hand hygiene and sanitization of various surfaces. This study endeavors to comprehensively evaluate the impacts of these disinfectants when introduced into the respiratory airway system.

Methods: In the context of disinfectant classification, this study subjected representative disinfectants, namely ethanol, hydrogen peroxide, and sodium hypochlorite, to a range of concentrations and exposure durations on respiratory cell lines and nasal mucosal tissues, investigating a spectrum of effects.

Results: Despite the brief exposure to low concentrations of all enrolled disinfectants, BEAS-2B cells exhibited a significant rise in pro-inflammatory cytokines in comparison to the control group. Notably, we observed the dissociation of the mucosal epithelial layer in response to ethanol at 1000 ppm, hydrogen peroxide at 1 ppm, and sodium hypochlorite at 10 ppm. Furthermore, a reduction in the motility of cilia, responsible for the physical defense of the epithelial layer, was evident at concentrations of 1000 ppm ethanol and 1 ppm hydrogen peroxide.

Conclusions: Disinfectants used to prevent COVID-19 may induce inflammation and tissue damage even at low concentrations in airway cells and tissues, necessitating cautious usage, even in small amounts. KEY WORDS: COVID-19, disinfectants, safety, airway, nasal mucosa Level of Evidence: 5

목차 (Table of Contents)

• 서론 1
• 연구 방법 4
• 결과 6
• 토의 9
• 결론 13
• 참고 문헌 15