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    Anti-obesity and anti-diabetic effects through PPP5 inhibition using norcantharidin

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    https://www.riss.kr/link?id=T16973830

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

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    Protein serine/threonine phosphatase (PSP) maintains appropriate serine and threonine levels in cells through PSK and antagonism. Such overexpression of PSPs participates in the signal action of cells and induces cell division, cell self-destruction, and metabolic diseases such as obesity and diabetes. It is known that the loss of STP, a type of PPP5, inhibits the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Screening of 1,153 natural products revealed that Norcantharidin effectively inhibits PPP5. Furthermore, Western blot analysis of fat and diabetes-related markers after PPP5 knockdown showed that PPP5 inhibition has potential as a treatment for obesity and diabetes.
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    Protein serine/threonine phosphatase (PSP) maintains appropriate serine and threonine levels in cells through PSK and antagonism. Such overexpression of PSPs participates in the signal action of cells and induces cell division, cell self-destruction, ...

    Protein serine/threonine phosphatase (PSP) maintains appropriate serine and threonine levels in cells through PSK and antagonism. Such overexpression of PSPs participates in the signal action of cells and induces cell division, cell self-destruction, and metabolic diseases such as obesity and diabetes. It is known that the loss of STP, a type of PPP5, inhibits the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Screening of 1,153 natural products revealed that Norcantharidin effectively inhibits PPP5. Furthermore, Western blot analysis of fat and diabetes-related markers after PPP5 knockdown showed that PPP5 inhibition has potential as a treatment for obesity and diabetes.

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    목차 (Table of Contents)

    • Abstract I
    • Chapter 1. Introduction 1
    • 1.1 Definition and risk of obesity and T2DM 1
    • 1.2 T2DM 2
    • 1.3 PPP5 3
    • Abstract I
    • Chapter 1. Introduction 1
    • 1.1 Definition and risk of obesity and T2DM 1
    • 1.2 T2DM 2
    • 1.3 PPP5 3
    • Chapter 2. Material and Methods 5
    • 2.1 Overexpression and Purification of Recombinant PPP5 5
    • 2.2 Half-Maximal Inhibitory Concentration (IC50) Determination 6
    • 2.3 RNA interference 7
    • 2.4 Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) 7
    • 2.5 Cell Culture and Differentiation Mouse 3T3-L1 pre-adipocytes 8
    • 2.6 Glucose uptake assays 10
    • 2.7 Western Blotting 11
    • 2.8 Oil Red O Staining 12
    • 2.9 Statistical Analysis 12
    • Chapter 3. Results 13
    • 3.1 The path to discovering natural products that inhibit PPP5 13
    • 3.2 Suppression of PPP5 increased obesity and diabetes marker 16
    • 3.3 Norcantharidin derivatives 17
    • 3.4 The cytotoxicity of NCT in 3T3-L1 21
    • 3.5 Norcantharidin downregulated the adipogenic
    • transcriptional Factors 22
    • 3.6 Treatment with Norcantharidin increases
    • p-AMPK and p-AKT levels 24
    • 3.7 Glucose uptake is increased following NCT treatment 25
    • 3.8 Effects of NCT on lipid accumulation of 3T3-L1 26
    • Chapter 4. Conclusion 28
    • Chapter 5. References 30
    • 국문초록
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