Antinociceptive effects of spirulina in a fibromyalgia mouse model = 섬유근통 동물모델에서 스피루리나의 항통증 효과

다국어 초록 (Multilingual Abstract)

Edible microalgae (Chlorella, Haematococcus, and Spirulina spp.), which are globally used as nutraceuticals and food additives, may provide health benefits against infection, inflammation, and neurological disorders. Spirulina (SP) treatment during adolescence can protect against adolescent stress-induced behavioral, biochemical, and neuroanatomical impairments in adulthood. Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia syndrome (FMS). Stress is an important risk factor in the development of depression and memory impairments. In this study, our aim was to determine whether SP might have beneficial effects on pain sensitivity via a brain-derived neurotrophic factor (BDNF) pathway. To assess the possible effect of SP on FMS symptoms, we used an FMS mouse model of stress induced by restraint with intermittent cold stress. Subsequently, we aimed to measure the antinociceptive effects of SP components in the FMS mouse model following the oral administration of SP extracts. In the behavioral analysis, nociception tests showed that the pain threshold was significantly decreased in the FMS group compared to the control group. SP treatment prevented these changes in behavioral actions and protein expression. Our results suggest that SP might potentially have therapeutic efficacy for FMS. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNF-CREB pathway and pain. Further research studies using cellular and animal model systems are required to characterize pharmacological functions and signal transduction pathways of drugs in this fibromyalgia animal model.

목차 (Table of Contents)

• Figure index Ⅲ
• Abstract Ⅳ
• Ⅰ. Introduction 1
• Ⅱ. Materials&Methods 5
• Ⅲ. Results 13
• Ⅳ. Discussion 25
• Reference 29
• 국문요약 39