Cimetidine과 Phenobarbital이 Acetaminophen에 依한 急性肝毒性에 미치는 影響에 關한 硏究 = Biochemical and pathological studies on effects of pretreated cimetidine and phenobarbital upon acute hepatic lesions induced by large amount of acetaminophen

다국어 초록 (Multilingual Abstract)

In an attempt to elucidate the biochemical mechanism and efffects of phenobarbital and cimetidine on acetaminophen-induced hepatic necrosis, the present study in rats was undertaken to evaluate the relation between serum transaminase and pathologic change of the liver at 3. 6, 12 and 24 hours after acetaminophen administration with pretreatment of phenobarbital and cimetidine.
The results were as follows:
1.Twenty-four hour mortalities in acetaminophen 600mg/kg administrated groups are 3.3% for the control group, 3.3% for cimetidine pretreatment group and 16.6% for the phenobarbital pretreatment group, respectively.
In acetaminophen 1200mg/kg administrated groups, the mortalities are 33.3%, 6.6 % and 43% respectively.
2.The sGOT activity is increased at 3 hours after acetaminophen administration, and is in proportion to the dose of the drugs. In animals pretreated with cimetidine the elevation of the sGOT is decreased, but is increased in phenobarbital preated groups.
The change of the sGPT is similiar to the sGOT, and reveal striking elevation at 24 hour after acetaminophen administration.
3.In animals receiving acetaminophen 600mg/kg, the necrotic change of the liver is not observed in the cimetidine pretreated group, but present in the phenobarbital pretreated group at 12 hours after acetaminophen administration.
4.In animals receiving acetaminophen 1200mg/kg, necrotic change is well demonstrated in the experimental and control group at 12 hours and 24 hours after acetaminohen administration. The severity of necrotic change is mild in the cimetidine pretreated group but severe in the phenobarbital pretreated group in contrast to the control group.
In summary, the results obtained by the present study indicate the severity of hepatic necrosis in the acetaminophen overdose treated rats is in proportion to the dose, increased by phenobarbital and decreased 'by cimetidine.

목차 (Table of Contents)

• 목차
• I. 緖論 = 1
• II. 實驗材料 및 方法 = 2
• III. 實驗結果 = 4
• IV. 考察 = 6
• V. 結論 = 8
• 參考文獻 = 9
• Summary = 12
• 寫眞說明 = 14
• 寫眞 = 15