Photoprotective effect of 3-hydroxy-5,6-epoxy-β- ionone isolated from Sargassum horneri

다국어 초록 (Multilingual Abstract)

Ultraviolet (UV) B is one of the types of UV light that possesses significant energy, and overexposure to UVB leads to various skin damage. In our previous study, we obtained a single compound, 3-hydroxy-5,6-epoxy-β-ionone (HEBI) from Sargassum horneri, which exhibited significant anti-inflammatory activity. We aimed to explore the photoprotective effect of HEBI against UVB in this study, through human keratinocytes, human dermal fibroblasts (HDF) cell and zebrafish model. The results demonstrated that HEBI considerably enhanced cell viability, scavenged reactive oxygen species (ROS), and reduced apoptosis in UVB-mediated HaCaT cells.
In UVB-mediated HDF cells, HEBI effectively mitigated oxidative stress, promoted collagen production, and downregulated the expression of matrix metalloproteinases and pro-inflammatory cytokines. Additionally, HEBI treatment effectively inhibited UVB-triggered lipid peroxidation and cell death photodamage in zebrafish by scavenging ROS and nitric oxide. Therefore, we suggested that HEBI possesses a strong photoprotective effect and can be used in cosmetics and pharmaceuticals.