전기방사법을 이용한 유용성 생리활성성분을 포함한 고분자 마이크로입자 제조 = Electrospray-assisted Preparation of Polymer Microparticles Containing Water-insoluble Bioactive Compounds

다국어 초록 (Multilingual Abstract)

An anti-aging compound ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) rapidly crystallizes in emulsion systems, and a flavonoid 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone bearing a whitening function causes coloration of cosmetic compounds when mixed with metal oxides. In this study, an electrospray method was used to encapsulate water-insoluble bioactive compounds in polymeric microparticles. Poly (methyl methacrylate) and polycaprolactone were used to encapsulate ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) and 3,5,7-trihydroxy- 4’-methoxy-8-prenylflavone, respectively. It was found that polymer concentration, the structure of electrospray nozzle, and compatibility between polymers and bioactive compounds were important factors in the preparation of the particles. Polycaprolactone particles encapsulating 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone was effective in preventing coloration of a cosmetic compound when mixed with metal oxides.

참고문헌 (Reference)

1 Y. K. Hwang, "Production of uniform-sized polymer core−shell microcapsules by coaxial electrospraying" 24 (24): 2446-, 2008

2 Y. Xia, "One-dimensional nanostructures: synthesis, characterization, and applications" 15 (15): 353-, 2003

3 "Korea Patent 1020070115256"

4 "Korea Patent 1020060090560"

5 E. C. Cho, "Internal structure and size matters of polyester nanoparticles encapsulating a bioactive hydrophobic drug for the prevention of drug crystals in aqueous systems" 51 (51): 11137-, 2012

6 P. Opanasopit, "Electrospun poly (vinyal lcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen" 59 (59): 233-, 2008

7 T. J. Sill, "Electrospinning: applications in drug delivery and tissue engineering" 29 (29): 1989-, 2008

8 A. Greiner, "Electrospinning: a fascinating method for the preparation of ultrathin fibers" 46 (46): 5670-, 2007

9 D. Li, "Electrospinning of nanofibers: reinventing the wheel?" 16 (16): 1151-, 2004

10 J. N. Smith, "Droplet evaporation and discharge dynamics in electrospray ionization" 106 (106): 9957-, 2002