흡연상태가 40세 이상 남성의 만성폐쇄성폐질환 유병가능성에 미치는 영향: 제5기 국민건강영양조사를 기반으로 = Effects of Smoking Status on Chronic Obstructive Pulmonary Disease Prevalence in Males 40 years and Older: Findings from the Korean National Health and Nutrition Examination Survey

다국어 초록 (Multilingual Abstract)

Background: This is a study of the prevalence of chronic obstructive pulmonary disease (COPD), which showshigh mortality worldwide, and the effects of smoking on COPD by using data from the Korea National Healthand Nutrition Examination Survey V.
Methods: FEV1/FEV6<0.73 was used as a diagnostic criterion of COPD. Frequency analysis for prevalence, descriptivestatistics for general characteristics and ventilation rate according to age-specifications, and complexsample logistic regression analysis for the effect of smoking on COPD prevalence were used. IBM SPSSStatistics 21 Standard, Complex Samples for Medical Science(Windows) was used for data analysis(α=0.05).
Results: Prevalence of COPD was 11.6±0.5% of Koreans in their forties or over, and 17.5±0.8% in males, and6.2±0.5% in females. There was significant increase of COPD prevalence with age increment. Before adjustingfor age and smoking index(SI), the COPD possibilities of past and current-smokers compared with non-smokingmales were (odds ratio [OR] 2.112 [95% confidence interval [CI] 1.551-2.875]) and (OR 1.834 [95% CI1.319-2.551]) respectively. After adjustments with age and SI, the COPD possibility of current-smoking was2.099 (1.382-3.188) times higher and for past-smoking was 1.463 (1.012-2.115) times higher than non-smoking.
The P-value of each group was significant. The regression coefficients (B) of current-smoking and past-smokingwere 0.741 and 0.380 respectively. The prevalence of COPD increased 1.102 (1.090-1.115) times for every1 year of age increase, and 1.012 (1.007-1.018) times for every 1 SI increase (P<0.001).
Conclusions: After adjusting for age and SI, the prevalence of COPD in smokers was higher than non-smokers.
And current-smoking had a higher OR and higher B than past-smoking.

국문 초록 (Abstract)

연구배경: 국민건강영양조사 제5기 건강검진조사 자료를활용하여 COPD 유병률과, 흡연상태가 이 질병발생에 미치는 영향을 조사하였다.
방법: COPD 진단기준은 FEV1/FEV6<0.73, 흡연이 COPD유병률에 미치는 영향은 복합표본설계 로지스틱회귀분석을 하였다.
결과: 40세 이상 COPD 유병률은 11.6±0.5%였고, 남성은17.5±0.8%, 여성은 6.2±0.5%였다. 남성의 보정 전 COPD유병가능성은 현재흡연자는 OR 1.834 (95% CI 1.319-2.551),과거흡연자는 OR 2.112 (95% CI 1.551-2.875)였다. 연령과흡연지수를 보정한 현재흡연자의 유병가능성은 2.099(1.382-3.188)배 과거흡연자는 1.463 (1.012-2.115)배였으며각 군의 유의도는 0.001과 0.043으로 유의하였다(현재흡연의 회귀계수는 0.741±0.213, 과거흡연은 0.380±0.188). 연령 1세 증가시마다 유병가능성이 1.102 (1.090-1.115)배 증가하였고, 흡연지수가 1 pack*year 증가시마다 1.012 (1.007-1.018)배 증가하였다(P<0.001).
결론: 연령과 흡연량 보정 후, 흡연자의 COPD 유병가능성이 높았다. 또한 현재흡연자는 과거흡연자보다 승산비와 회귀계수가 더 높았다.

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